MolNFT v1 · #186967 · protein
Crystal structure of CDK2 liganded with compound GPHR787
7RWE · Cyclin-dependent kinase 2: “Crystal structure of CDK2 liganded with compound GPHR787”. X-ray diffraction, 1 ligand (7TH), 2 pockets (best druggability 0.67). MolNFT v1 #186967 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7RWE
- Type
- protein
- Length
- 254 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 2
- EC
- 2.7.11.22
- UniProt
- P24941
- Ligands
- 7TH
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinase 2 (EC 2.7.11.22) | protein | 254 | 36% helix, 14% strand | P24941 |
Ligands and binding sites
- 7TH · 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 143 | 0.67 | 0.88 | 24 | 7TH |
| 2 | 191 | 0.61 | 0.82 | 23 | 7TH |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Elsewhere: RCSB PDB 7RWE · PDBe 7RWE · UniProt P24941
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