MolNFT v1 · #186865 · protein
Structure of the VPS34 kinase domain with compound 5
7RSV: “Structure of the VPS34 kinase domain with compound 5”. X-ray diffraction, 2 ligands (7IQ, NA). MolNFT v1 #186865 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RSV
- Type
- protein
- Length
- 1,063 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8NEB9
- Ligands
- 7IQ, NA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 529 | — | Q8NEB9 |
| B | — | protein | 534 | — | Q8NEB9 |
Ligands and binding sites
- 7IQ · (5as,8ar,9s)-2-[(3R)-3-methylmorpholin-4-yl]-5,5A,6,7, 8,8A-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · 5 copies · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RSV · Structure of the VPS34 kinase domain with compound 5 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NEB9 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NEB9
- Elsewhere: RCSB PDB 7RSV · PDBe 7RSV · UniProt Q8NEB9
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