MolNFT v1 · #186808 · protein

Arabidopsis RNA-dependent RNA polymerase 2

7RQS: “Arabidopsis RNA-dependent RNA polymerase 2”. Electron microscopy, 1 ligand (MG), 14 pockets (best druggability 0.81). MolNFT v1 #186808 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RQS
Type: protein
Length: 1,074 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase 2
EC: 2.7.7.48
UniProt: O82504
Ligands: MG
Pockets: 14 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 33% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase 2 (EC 2.7.7.48)	protein	1074	33% helix, 19% strand	O82504

Ligands and binding sites

MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	961	0.81	0.83	151	empty
2	152	0.74	0.92	29	empty
3	1123	0.74	0.77	92	MG
4	364	0.71	0.83	35	empty
5	62	0.67	0.95	21	empty

Compared structures

7RQS · Arabidopsis RNA-dependent RNA polymerase 2 · the same entry in another collection · chain A against A, TM-score 1.00
O82504 · AlphaFold monomer V2.0 prediction for RNA-dependent RNA polymerase 2 (O82504) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O82504
Elsewhere: RCSB PDB 7RQS · PDBe 7RQS · UniProt O82504

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