UniProt O82504
RNA-dependent RNA polymerase 2 (O82504)
RNA-dependent RNA polymerase 2 (UniProt O82504), EC 2.7.7.48: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O82504
- Protein
- RNA-dependent RNA polymerase 2
- EC
- 2.7.7.48
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 44 · 5 records with a druggable one
Structures
9 records of O82504 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EU0 | The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | electron microscopy | M | MG | 8 (best 0.89) |
| 7EU0 | The cryo-EM structure of a. thaliana pol IV-RDR2 backtracked complex | electron microscopy | M | MG | — |
| 7EU1 | The cryo-EM structure of a. thaliana pol IV-RDR2 holoenzyme | electron microscopy | M | MG | — |
| 7ROZ | Structure of RNA-dependent RNA polymerase 2 (RDR2) from arabidopsis thaliana | electron microscopy | A | MG | — |
| 7RQS | Arabidopsis RNA-dependent RNA polymerase 2 | electron microscopy | A | MG | — |
| 8XMB | NTP-bound Pol IV transcription elongation complex | electron microscopy | M | — | 6 (best 0.81) |
| 8XMD | Pre-translocated Pol IV transcription elongation complex | electron microscopy | M | — | 7 (best 0.80) |
| 8XME | Backtracked Pol IV transcription elongation complex | electron microscopy | M | — | 7 (best 0.81) |
| O82504 | AlphaFold monomer V2.0 prediction for RNA-dependent RNA polymerase 2 (O82504) | predicted | A | — | 16 (best 0.83) |
Ligands
- MG · Magnesium ion · in 5 records
Experiment against prediction
- 7EU0 chain M against the predicted model O82504: TM-score 0.97, RMSD 1.84 Å
- 7EU0 chain M against the predicted model O82504: TM-score 0.97, RMSD 1.84 Å
- 8XMB chain M against the predicted model O82504: TM-score 0.97, RMSD 1.92 Å
- 8XME chain M against the predicted model O82504: TM-score 0.97, RMSD 1.94 Å
- 8XMD chain M against the predicted model O82504: TM-score 0.97, RMSD 1.94 Å
- 7EU1 chain M against the predicted model O82504: TM-score 0.97, RMSD 2.06 Å
- 7RQS chain A against the predicted model O82504: TM-score 0.95, RMSD 2.38 Å
- 7ROZ chain A against the predicted model O82504: TM-score 0.95, RMSD 2.60 Å
Elsewhere
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