SH2 domain of guanine nucleotide exchange factor VAV2 in complex with an actin peptide with phosphorylated tyrosine 53

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 33% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 366 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

• 7RNV · SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide… · the same entry in another collection · chain A against A, TM-score 1.00
• P52735 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange factor VAV2 (P52735) · a predicted model of the same protein · chain A against A, TM-score 0.95
• P68133 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68133) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P52735
• Every structure of UniProt P68133
• Elsewhere: RCSB PDB 7RNV · PDBe 7RNV · UniProt P52735 · UniProt P68133