UniProt P68133
Actin, alpha skeletal muscle (P68133)
Actin, alpha skeletal muscle (UniProt P68133), EC 3.6.4.-: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P68133
- Protein
- Actin, alpha skeletal muscle
- EC
- 3.6.4.-
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 40 · 2 records with a druggable one
Structures
8 records of P68133 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7RNS | nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide… | x-ray diffraction | B | — | — |
| 7RNS | NSH2 domain of P85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide… | x-ray diffraction | B | — | — |
| 7RNU | NSH2 domain of P85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide… | x-ray diffraction | B, D, F, H | — | — |
| 7RNV | SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with… | x-ray diffraction | B | — | — |
| 7RNV | SH2 domain of guanine nucleotide exchange factor VAV2 in complex with an actin peptide with… | x-ray diffraction | B | — | — |
| 9DUU | Cryo-EM structure of recombinant wildtype ACTA1 phalloidin-stabilized F-actin | electron microscopy | A, B, C, D, E, F | ADP, MG | 20 (best 0.84) |
| 9DUV | Cryo-EM structure of recombinant R254H ACTA1 phalloidin-stabilized F-actin | electron microscopy | A, B, C, D, E, F | ADP, MG | 20 (best 0.81) |
| P68133 | AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68133) | predicted | A | — | — |
Ligands
Experiment against prediction
- 9DUU chain B against the predicted model P68133: TM-score 0.96, RMSD 1.58 Å
- 9DUV chain B against the predicted model P68133: TM-score 0.96, RMSD 1.57 Å
- 9DUU chain C against the predicted model P68133: TM-score 0.96, RMSD 1.59 Å
- 9DUU chain A against the predicted model P68133: TM-score 0.96, RMSD 1.59 Å
- 9DUV chain E against the predicted model P68133: TM-score 0.96, RMSD 1.58 Å
- 9DUV chain D against the predicted model P68133: TM-score 0.96, RMSD 1.58 Å
- 9DUU chain D against the predicted model P68133: TM-score 0.96, RMSD 1.60 Å
- 9DUU chain F against the predicted model P68133: TM-score 0.96, RMSD 1.62 Å
- 9DUV chain A against the predicted model P68133: TM-score 0.96, RMSD 1.59 Å
- 9DUV chain C against the predicted model P68133: TM-score 0.96, RMSD 1.59 Å
Elsewhere
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