MolNFT v1 · #186730 · protein
Estrogen receptor alpha ligand binding domain Y537S mutant in complex with 2-(2-chloro-5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4-YL)ISOINDOLIN-5-ol and grip peptide
7RNM: “Estrogen receptor alpha ligand binding domain Y537S mutant in complex with…”. X-ray diffraction, 1 ligand (61Z). MolNFT v1 #186730 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RNM
- Type
- protein
- Length
- 465 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372, E7EWM1
- Ligands
- 61Z
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 219 | — | P03372 |
| B | — | protein | 229 | — | P03372 |
| C | — | protein | 8 | — | E7EWM1 |
| D | — | protein | 9 | — | E7EWM1 |
Ligands and binding sites
- 61Z · 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RNM · Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Every structure of UniProt E7EWM1
- Elsewhere: RCSB PDB 7RNM · PDBe 7RNM · UniProt P03372 · UniProt E7EWM1
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