MolNFT v1 · #186649 · protein
Crystal structure of the human cytochrome P450 2C9*8 (CYP2C9*8) genetic variant in complex with the drug losartan
7RL2: “Crystal structure of the human cytochrome P450 2C9*8 (CYP2C9*8) genetic variant in complex with the drug…”. X-ray diffraction, 4 ligands (LSN, HEM, K). MolNFT v1 #186649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RL2
- Type
- protein
- Length
- 463 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P11712
- Ligands
- LSN, HEM, K, PO4
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 463 | — | P11712 |
Ligands and binding sites
- LSN · [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol · ligand · 2 copies · chains A
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- K · Potassium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RL2 · Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in… · the same entry in another collection · chain A against A, TM-score 1.00
- P11712 · AlphaFold monomer V2.0 prediction for cytochrome P450 2C9 (P11712) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11712
- Elsewhere: RCSB PDB 7RL2 · PDBe 7RL2 · UniProt P11712
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