Crystal structure of the human cytochrome P450 2C9*8 (CYP2C9*8) genetic variant in complex with the drug losartan

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 10% strand (DSSP).

Ligands and binding sites

• LSN · [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol · ligand · 2 copies · chains A
• HEM · Protoporphyrin IX containing Fe · ligand · chains A
• K · Potassium ion · metal · chains A
• PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 7RL2 · Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in… · the same entry in another collection · chain A against A, TM-score 1.00
• P11712 · AlphaFold monomer V2.0 prediction for cytochrome P450 2C9 (P11712) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11712
• Elsewhere: RCSB PDB 7RL2 · PDBe 7RL2 · UniProt P11712