Crystal structure of human bromodomain containing protein 4 (BRD4) in complex with shmt

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 0% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 8 copies · chains A
• CL · Chloride ion · ion · 4 copies · chains A, B
• EDO · 1,2-ethanediol · additive · chains A
• GOL · Glycerol · additive

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 528 Ų buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 7RJP · Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with SHMT · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P34896 · AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase, cytosolic (P34896) · a predicted model of the same protein · chain B against A, TM-score 0.49

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt P34896
• Elsewhere: RCSB PDB 7RJP · PDBe 7RJP · UniProt O60885 · UniProt P34896