UniProt P34896
Serine hydroxymethyltransferase, cytosolic (P34896)
Serine hydroxymethyltransferase, cytosolic (UniProt P34896), EC 2.1.2.1: 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P34896
- Protein
- Serine hydroxymethyltransferase, cytosolic
- EC
- 2.1.2.1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 40 · 2 records with a druggable one
Structures
10 records of P34896 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BJ4 | Recombinant serine hydroxymethyltransferase (human) | x-ray diffraction | A | — | — |
| 1BJ4 | Recombinant serine hydroxymethyltransferase (human) | x-ray diffraction | A | — | — |
| 6FL5 | Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution | x-ray diffraction | A, D, G, J | PLP, CL | 20 (best 0.83) |
| 6FL5 | Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 ang. resolution | x-ray diffraction | A, D, G, J | PLP, CL | — |
| 6M5W | Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with pyridoxal… | x-ray diffraction | A | PLP, DXC | — |
| 7RJL | Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with SHMT | x-ray diffraction | C | — | — |
| 7RJL | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with shmt | x-ray diffraction | C | — | — |
| 7RJP | Crystal structure of human bromodomain containing protein 4 (BRD4) in complex with shmt | x-ray diffraction | B | CL | — |
| 8A11 | Cryo-EM structure of the Human SHMT1-RNA complex | electron microscopy | A, B, C, D | PLP | 20 (best 0.81) |
| P34896 | AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase, cytosolic (P34896) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6FL5 chain G against the predicted model P34896: TM-score 1.00, RMSD 0.52 Å
- 6FL5 chain G against the predicted model P34896: TM-score 1.00, RMSD 0.52 Å
- 6FL5 chain D against the predicted model P34896: TM-score 0.99, RMSD 0.58 Å
- 6FL5 chain D against the predicted model P34896: TM-score 0.99, RMSD 0.58 Å
- 6FL5 chain J against the predicted model P34896: TM-score 0.99, RMSD 0.58 Å
- 6FL5 chain J against the predicted model P34896: TM-score 0.99, RMSD 0.58 Å
- 1BJ4 chain A against the predicted model P34896: TM-score 0.99, RMSD 0.60 Å
- 1BJ4 chain A against the predicted model P34896: TM-score 0.99, RMSD 0.60 Å
- 6FL5 chain A against the predicted model P34896: TM-score 0.99, RMSD 0.60 Å
- 6FL5 chain A against the predicted model P34896: TM-score 0.99, RMSD 0.60 Å
Elsewhere
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