Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with hnrnpk

Structure

x-ray diffraction · 3 distinct chains · 53% helix, 0% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · 2 copies · chains B, A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, C, B
• GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–B · 1020 Ų buried · 12 hydrogen bonds · protein-protein
• A–C · 685 Ų buried · 6 hydrogen bonds · protein-protein
• B–D · 671 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (acetylation).

Compared structures

• 7RJK · Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with hnRNPK · the same entry in another collection · chain D against D, TM-score 1.00
• Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain B against A, TM-score 0.97
• P61978 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein K (P61978) · a predicted model of the same protein · chain C against A, TM-score 0.40

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15059
• Every structure of UniProt P61978
• Elsewhere: RCSB PDB 7RJK · PDBe 7RJK · UniProt Q15059 · UniProt P61978