MolNFT v1 · #186346 · protein
Small conductance mechanosensitive channel mscs
7RAZ · Small-conductance mechanosensitive channel: “Small conductance mechanosensitive channel mscs”. Electron microscopy, 1 ligand (PTY), 16 pockets (best druggability 0.65). MolNFT v1 #186346 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7RAZ
- Type
- protein
- Length
- 1,330 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small-conductance mechanosensitive channel
- UniProt
- P0C0S1
- Ligands
- PTY
- Pockets
- 16 · best druggability 0.65
Structure
electron microscopy · 1 distinct chain · 38% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Small-conductance mechanosensitive channel | protein | 190 | 38% helix, 30% strand | P0C0S1 |
Ligands and binding sites
- PTY · Phosphatidylethanolamine · ligand · 7 copies · chains A, B, C, D, E, F, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 279 | 0.65 | 0.81 | 29 | empty |
| 2 | 384 | 0.59 | 0.76 | 87 | empty |
| 3 | 516 | 0.56 | 0.72 | 53 | empty |
| 4 | 113 | 0.46 | 0.78 | 20 | empty |
| 5 | 128 | 0.46 | 0.77 | 24 | empty |
Interfaces
14 interfaces between chains.
- A–B · 2305 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 2278 Ų buried · 21 hydrogen bonds · protein-protein
- F–G · 2267 Ų buried · 25 hydrogen bonds · protein-protein
- E–F · 2259 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 2255 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7RAZ · Small conductance mechanosensitive channel MscS · the same entry in another collection · chain G against G, TM-score 1.00
- P0C0S1 · AlphaFold monomer V2.0 prediction for small-conductance mechanosensitive channel (P0C0S1) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0S1
- Elsewhere: RCSB PDB 7RAZ · PDBe 7RAZ · UniProt P0C0S1
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