MolNFT v1 · #186241 · protein
Structure of human SHP2 in complex with compound 22
7R7D: “Structure of human SHP2 in complex with compound 22”. X-ray diffraction, 1 ligand (37I). MolNFT v1 #186241 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7R7D
- Type
- protein
- Length
- 984 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q06124
- Ligands
- 37I
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 489 | — | Q06124 |
| B | — | protein | 495 | — | Q06124 |
Ligands and binding sites
- 37I · 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine · ligand · 2 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7R7D · Structure of human SHP2 in complex with compound 22 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 7R7D · PDBe 7R7D · UniProt Q06124
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