MolNFT v1 · #186197 · protein
In vitro assembled 266/297 - 391 tau filaments with kcl (10B)
7R5H · Microtubule-associated protein tau: “In vitro assembled 266/297 - 391 tau filaments with kcl (10B)”. Electron microscopy, 6 pockets (best druggability 0.58). MolNFT v1 #186197 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7R5H
- Type
- protein
- Length
- 477 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 6 · best druggability 0.58
Structure
electron microscopy · 2 distinct chains · 0% helix, 64% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Microtubule-associated protein tau | protein | 84 | 0% helix, 63% strand | P10636 |
| D, E, F | Microtubule-associated protein tau | protein | 75 | 0% helix, 65% strand | P10636 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 449 | 0.58 | 0.74 | 57 | empty |
| 2 | 136 | 0.50 | 0.79 | 25 | empty |
| 3 | 206 | 0.47 | 0.74 | 31 | empty |
| 4 | 68 | 0.46 | 0.83 | 18 | empty |
| 5 | 85 | 0.40 | 0.77 | 14 | empty |
Interfaces
15 interfaces between chains.
- A–C · 3560 Ų buried · 96 hydrogen bonds · protein-protein
- A–B · 3543 Ų buried · 102 hydrogen bonds · protein-protein
- D–E · 3162 Ų buried · 92 hydrogen bonds · protein-protein
- D–F · 3162 Ų buried · 90 hydrogen bonds · protein-protein
- B–D · 257 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7R5H · In vitro assembled 266/297 - 391 tau filaments with KCl (10b) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7R5H · PDBe 7R5H · UniProt P10636
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.