MolNFT v1 · #186184 · protein
In vitro assembled 266/297 - 391 tau filaments with NAHCO3 and nacl (16A)
7R4T · Microtubule-associated protein tau: “In vitro assembled 266/297 - 391 tau filaments with NAHCO3 and nacl (16A)”. Electron microscopy, 6 pockets (best druggability 0.54). MolNFT v1 #186184 on GenesisL1: 3D structure, binding sites…
- PDB
- 7R4T
- Type
- protein
- Length
- 456 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 6 · best druggability 0.54
Structure
electron microscopy · 1 distinct chain · 0% helix, 64% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F, A, B, C, D, E | Microtubule-associated protein tau | protein | 76 | 0% helix, 64% strand | P10636 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.54 | 0.81 | 25 | empty |
| 2 | 147 | 0.53 | 0.80 | 26 | empty |
| 3 | 226 | 0.48 | 0.74 | 29 | empty |
| 4 | 55 | 0.46 | 0.84 | 16 | empty |
| 5 | 55 | 0.45 | 0.84 | 17 | empty |
Interfaces
9 interfaces between chains.
- A–C · 3179 Ų buried · 84 hydrogen bonds · protein-protein
- F–B · 3172 Ų buried · 85 hydrogen bonds · protein-protein
- F–D · 3171 Ų buried · 84 hydrogen bonds · protein-protein
- A–E · 3166 Ų buried · 83 hydrogen bonds · protein-protein
- C–D · 84 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7R4T · In vitro assembled 266/297 - 391 tau filaments with NaHCO3 and NaCl (16a) · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7R4T · PDBe 7R4T · UniProt P10636
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