MolNFT v1 · #186181 · protein
Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl- 5-(METHYLAMINO)PYRIMIDINE-2,4(1H,3H)-dione
7R4P: “Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl…”. X-ray diffraction, 2 ligands (FMN, I2Z), 3 pockets (best druggability 0.79). MolNFT v1 #186181 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7R4P
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hydroxyacid oxidase 1
- EC
- 1.1.3.15
- UniProt
- Q9UJM8
- Ligands
- FMN, I2Z
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hydroxyacid oxidase 1 (EC 1.1.3.15) | protein | 337 | 48% helix, 14% strand | Q9UJM8 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · chains A
- I2Z · 6-amino-1-benzyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.79 | 0.91 | 48 | FMN, I2Z |
| 2 | 145 | 0.51 | 0.79 | 26 | empty |
| 3 | 57 | 0.27 | 0.73 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJM8
- Elsewhere: RCSB PDB 7R4P · PDBe 7R4P · UniProt Q9UJM8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.