MolNFT v1 · #186179 · protein
Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl- 1H-indazole-3-carboxamide
7R4N: “Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl- 1H-indazole-3-carboxamide”. X-ray diffraction, 2 ligands (7RI, FMN), 4 pockets (best druggability 0.82). MolNFT v1 #186179 on GenesisL1: 3D structure, binding…
- PDB
- 7R4N
- Type
- protein
- Length
- 352 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hydroxyacid oxidase 1
- EC
- 1.1.3.15
- UniProt
- Q9UJM8
- Ligands
- 7RI, FMN
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hydroxyacid oxidase 1 (EC 1.1.3.15) | protein | 352 | 46% helix, 14% strand | Q9UJM8 |
Ligands and binding sites
- 7RI · 5-bromanyl-N-methyl-1H-indazole-3-carboxamide · ligand · chains A
- FMN · Flavin mononucleotide · ligand · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.82 | 0.94 | 46 | 7RI, FMN |
| 2 | 126 | 0.45 | 0.77 | 23 | empty |
| 3 | 51 | 0.32 | 0.78 | 16 | empty |
| 4 | 58 | 0.27 | 0.73 | 14 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJM8
- Elsewhere: RCSB PDB 7R4N · PDBe 7R4N · UniProt Q9UJM8
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