MolNFT v1 · #186054 · protein
Structural biology of the NS1 avian influenza protein subversion on the scribble cell polarity module
7QTU · Protein scribble homolog: “Structural biology of the NS1 avian influenza protein subversion on the scribble cell polarity module”. X-ray diffraction, 5 pockets (best druggability 0.60). MolNFT v1 #186054 on GenesisL1: 3D structure…
- PDB
- 7QTU
- Type
- protein
- Length
- 355 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein scribble homolog; Non-structural protein 1
- UniProt
- Q14160, Q6B3P2
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Protein scribble homolog | protein | 80 | 16% helix, 40% strand | Q14160 |
| D, C, F, H | Non-structural protein 1 | protein | 7 | 0% helix, 43% strand | Q6B3P2 |
| A | Protein scribble homolog | protein | 83 | 13% helix, 40% strand | Q14160 |
| E | Protein scribble homolog | protein | 80 | 16% helix, 43% strand | Q14160 |
| G | Protein scribble homolog | protein | 84 | 17% helix, 40% strand | Q14160 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.60 | 0.75 | 55 | empty |
| 2 | 80 | 0.50 | 0.84 | 17 | empty |
| 3 | 56 | 0.46 | 0.84 | 20 | empty |
| 4 | 98 | 0.38 | 0.76 | 22 | empty |
| 5 | 76 | 0.31 | 0.74 | 25 | empty |
Interfaces
11 interfaces between chains.
- E–F · 503 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 452 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 409 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 399 Ų buried · 9 hydrogen bonds · protein-protein
- B–G · 338 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7QTU · Structural biology of the NS1 avian influenza protein subversion on the Scribble cell… · the same entry in another collection · chain H against H, TM-score 1.00
- Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14160
- Every structure of UniProt Q6B3P2
- Elsewhere: RCSB PDB 7QTU · PDBe 7QTU · UniProt Q14160 · UniProt Q6B3P2
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