Research workbench
Structural biology of the NS1 avian influenza protein subversion on the scribble cell polarity module
Analyse Structural biology of the NS1 avian influenza protein subversion on the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QTU
- Type
- protein
- Length
- 355 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein scribble homolog; Non-structural protein 1
- UniProt
- Q14160, Q6B3P2
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Protein scribble homolog | protein | 80 | 16% helix, 40% strand | Q14160 |
| D, C, F, H | Non-structural protein 1 | protein | 7 | 0% helix, 43% strand | Q6B3P2 |
| A | Protein scribble homolog | protein | 83 | 13% helix, 40% strand | Q14160 |
| E | Protein scribble homolog | protein | 80 | 16% helix, 43% strand | Q14160 |
| G | Protein scribble homolog | protein | 84 | 17% helix, 40% strand | Q14160 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.60 | 0.75 | 55 | empty |
| 2 | 80 | 0.50 | 0.84 | 17 | empty |
| 3 | 56 | 0.46 | 0.84 | 20 | empty |
| 4 | 98 | 0.38 | 0.76 | 22 | empty |
| 5 | 76 | 0.31 | 0.74 | 25 | empty |
Interfaces
11 interfaces between chains.
- E–F · 503 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 452 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 409 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 399 Ų buried · 9 hydrogen bonds · protein-protein
- B–G · 338 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7QTU · Structural biology of the NS1 avian influenza protein subversion on the Scribble cell… · the same entry in another collection · chain H against H, TM-score 1.00
- Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14160
- Every structure of UniProt Q6B3P2
- Elsewhere: RCSB PDB 7QTU · PDBe 7QTU · UniProt Q14160 · UniProt Q6B3P2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.