MolNFT v1 · #186033 · protein

Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5 protein

7QSB · Protein scribble homolog: “Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5…”. X-ray diffraction, 2 pockets (best druggability 0.33). MolNFT v1 #186033 on GenesisL1: 3D…

PDB: 7QSB
Type: protein
Length: 164 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein scribble homolog
UniProt: Q14160
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein scribble homolog	protein	84	17% helix, 32% strand	Q14160
B	Protein scribble homolog	protein	80	18% helix, 38% strand	Q14160

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.33	0.76	13	empty
2	57	0.32	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 516 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7QSB · Structural basis on the interaction of Scribble PDZ domains with the Tick Born… · the same entry in another collection · chain A against A, TM-score 1.00
Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14160
Elsewhere: RCSB PDB 7QSB · PDBe 7QSB · UniProt Q14160

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