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Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5 protein

Analyse Structural basis on the interaction of scribble PDZ domains with the tick born… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QSB
Type: protein
Length: 164 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein scribble homolog
UniProt: Q14160
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein scribble homolog	protein	84	17% helix, 32% strand	Q14160
B	Protein scribble homolog	protein	80	18% helix, 38% strand	Q14160

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.33	0.76	13	empty
2	57	0.32	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 516 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7QSB · Structural basis on the interaction of Scribble PDZ domains with the Tick Born… · the same entry in another collection · chain A against A, TM-score 1.00
Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14160
Elsewhere: RCSB PDB 7QSB · PDBe 7QSB · UniProt Q14160

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