MolNFT v1 · #185910 · protein

Structure of the rab gef complex MON1-CCZ1

7QLA · Vacuolar fusion protein MON1: “Structure of the rab gef complex MON1-CCZ1”. Electron microscopy, 9 pockets (best druggability 0.78). MolNFT v1 #185910 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7QLA
Type: protein
Length: 874 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vacuolar fusion protein MON1; CCZ1
UniProt: G0SGS3
Pockets: 9 · best druggability 0.78

Structure

electron microscopy · 2 distinct chains · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Vacuolar fusion protein MON1	protein	433	42% helix, 19% strand	G0SGS3
C	CCZ1	protein	441	35% helix, 21% strand	—

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1080	0.78	0.80	91	empty
2	397	0.77	0.87	55	empty
3	252	0.60	0.80	37	empty
4	250	0.57	0.78	31	empty
5	123	0.42	0.76	20	empty

Interfaces

1 interface between chains.

A–C · 1713 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

7QLA · Structure of the Rab GEF complex Mon1-Ccz1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SGS3
Elsewhere: RCSB PDB 7QLA · PDBe 7QLA · UniProt G0SGS3

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