Research workbench
Structure of the rab gef complex MON1-CCZ1
Analyse Structure of the rab gef complex MON1-CCZ1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QLA
- Type
- protein
- Length
- 874 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vacuolar fusion protein MON1; CCZ1
- UniProt
- G0SGS3
- Pockets
- 9 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vacuolar fusion protein MON1 | protein | 433 | 42% helix, 19% strand | G0SGS3 |
| C | CCZ1 | protein | 441 | 35% helix, 21% strand | — |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1080 | 0.78 | 0.80 | 91 | empty |
| 2 | 397 | 0.77 | 0.87 | 55 | empty |
| 3 | 252 | 0.60 | 0.80 | 37 | empty |
| 4 | 250 | 0.57 | 0.78 | 31 | empty |
| 5 | 123 | 0.42 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–C · 1713 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7QLA · Structure of the Rab GEF complex Mon1-Ccz1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGS3
- Elsewhere: RCSB PDB 7QLA · PDBe 7QLA · UniProt G0SGS3
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