MolNFT v1 · #185905 · protein
In vitro assembled 244-391 tau filaments with NA2P2O7 (20A)
7QL2 · Microtubule-associated protein tau: “In vitro assembled 244-391 tau filaments with NA2P2O7 (20A)”. Electron microscopy, 1 pocket (best druggability 0.47). MolNFT v1 #185905 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7QL2
- Type
- protein
- Length
- 150 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 1 · best druggability 0.47
Structure
electron microscopy · 1 distinct chain · 0% helix, 72% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C | Microtubule-associated protein tau | protein | 50 | 0% helix, 72% strand | P10636 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.47 | 0.78 | 31 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2188 Ų buried · 57 hydrogen bonds · protein-protein
- B–A · 2168 Ų buried · 58 hydrogen bonds · protein-protein
- A–C · 110 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7QL2 · In vitro assembled 244-391 tau filaments with Na2P2O7 (20a) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QL2 · PDBe 7QL2 · UniProt P10636
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