MolNFT v1 · #185900 · protein

In vitro assembled 266/297 - 391 tau filaments with MGSO4 and nacl (15B)

7QKX · Microtubule-associated protein tau: “In vitro assembled 266/297 - 391 tau filaments with MGSO4 and nacl (15B)”. Electron microscopy, 3 pockets (best druggability 0.55). MolNFT v1 #185900 on GenesisL1: 3D structure, binding sites and…

PDB: 7QKX
Type: protein
Length: 438 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 3 · best druggability 0.55

Structure

electron microscopy · 1 distinct chain · 0% helix, 62% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, B, D	Microtubule-associated protein tau	protein	73	0% helix, 62% strand	P10636

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.55	0.81	25	empty
2	139	0.52	0.79	23	empty
3	192	0.52	0.78	28	empty

Interfaces

11 interfaces between chains.

A–E · 3094 Å² buried · 82 hydrogen bonds · protein-protein
A–C · 3092 Å² buried · 80 hydrogen bonds · protein-protein
G–D · 3057 Å² buried · 78 hydrogen bonds · protein-protein
G–B · 3056 Å² buried · 82 hydrogen bonds · protein-protein
E–D · 111 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7QKX · In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15b) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 7QKX · PDBe 7QKX · UniProt P10636

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.