MolNFT v1 · #185899 · protein
In vitro assembled 266-391 S356D tau filaments with kcl (44A)
7QKW · Microtubule-associated protein tau: “In vitro assembled 266-391 S356D tau filaments with kcl (44A)”. Electron microscopy, 6 pockets (best druggability 0.49). MolNFT v1 #185899 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7QKW
- Type
- protein
- Length
- 306 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 6 · best druggability 0.49
Structure
electron microscopy · 2 distinct chains · 0% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C | Microtubule-associated protein tau | protein | 54 | 0% helix, 54% strand | P10636 |
| D, E, F | Microtubule-associated protein tau | protein | 48 | 0% helix, 58% strand | P10636 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.49 | 0.74 | 45 | empty |
| 2 | 79 | 0.49 | 0.83 | 15 | empty |
| 3 | 72 | 0.46 | 0.83 | 16 | empty |
| 4 | 76 | 0.46 | 0.82 | 23 | empty |
| 5 | 116 | 0.35 | 0.73 | 28 | empty |
Interfaces
11 interfaces between chains.
- B–C · 2177 Ų buried · 62 hydrogen bonds · protein-protein
- B–A · 2174 Ų buried · 58 hydrogen bonds · protein-protein
- D–F · 1980 Ų buried · 66 hydrogen bonds · protein-protein
- D–E · 1960 Ų buried · 61 hydrogen bonds · protein-protein
- A–E · 418 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7QKW · In vitro assembled 266-391 S356D tau filaments with KCl (44a) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QKW · PDBe 7QKW · UniProt P10636
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