MolNFT v1 · #185895 · protein

In vitro assembled 266-391 S356D tau filaments with nacl (45A)

7QKM · Microtubule-associated protein tau: “In vitro assembled 266-391 S356D tau filaments with nacl (45A)”. Electron microscopy, 2 pockets (best druggability 0.54). MolNFT v1 #185895 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7QKM
Type: protein
Length: 330 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 2 · best druggability 0.54

Structure

electron microscopy · 1 distinct chain · 0% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D, E, F	Microtubule-associated protein tau	protein	55	0% helix, 55% strand	P10636

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	277	0.54	0.75	22	empty
2	271	0.51	0.74	28	empty

Interfaces

11 interfaces between chains.

B–C · 2259 Å² buried · 69 hydrogen bonds · protein-protein
D–E · 2254 Å² buried · 69 hydrogen bonds · protein-protein
D–F · 2254 Å² buried · 67 hydrogen bonds · protein-protein
B–A · 2246 Å² buried · 68 hydrogen bonds · protein-protein
B–D · 231 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7QKM · In vitro assembled 266-391 S356D tau filaments with NaCl (45a) · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 7QKM · PDBe 7QKM · UniProt P10636

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