MolNFT v1 · #185881 · protein
In vitro assembled 258-391 tau filaments, 700 rpm (38A)
7QK3 · Microtubule-associated protein tau: “In vitro assembled 258-391 tau filaments, 700 rpm (38A)”. Electron microscopy, 2 pockets (best druggability 0.49). MolNFT v1 #185881 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7QK3
- Type
- protein
- Length
- 183 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 2 · best druggability 0.49
Structure
electron microscopy · 1 distinct chain · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C | Microtubule-associated protein tau | protein | 61 | 0% helix, 51% strand | P10636 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.49 | 0.74 | 34 | empty |
| 2 | 70 | 0.47 | 0.83 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–A · 2372 Ų buried · 79 hydrogen bonds · protein-protein
- B–C · 2359 Ų buried · 79 hydrogen bonds · protein-protein
- A–C · 15 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7QK3 · In vitro assembled 258-391 tau filaments, 700 rpm (38a) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QK3 · PDBe 7QK3 · UniProt P10636
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.