MolNFT v1 · #185880 · protein

In vitro assembled 300-391 tau filaments in pbs (36A)

7QK2 · Microtubule-associated protein tau: “In vitro assembled 300-391 tau filaments in pbs (36A)”. Electron microscopy, 5 pockets (best druggability 0.55). MolNFT v1 #185880 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7QK2
Type: protein
Length: 426 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 5 · best druggability 0.55

Structure

electron microscopy · 1 distinct chain · 0% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Microtubule-associated protein tau	protein	71	0% helix, 61% strand	P10636

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.55	0.81	21	empty
2	149	0.54	0.80	23	empty
3	52	0.41	0.83	23	empty
4	61	0.40	0.81	21	empty
5	95	0.36	0.75	14	empty

Interfaces

11 interfaces between chains.

A–B · 3496 Å² buried · 80 hydrogen bonds · protein-protein
A–C · 3495 Å² buried · 84 hydrogen bonds · protein-protein
D–E · 3488 Å² buried · 87 hydrogen bonds · protein-protein
D–F · 3465 Å² buried · 83 hydrogen bonds · protein-protein
B–C · 465 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7QK2 · In vitro assembled 300-391 tau filaments in PBS (36a) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 7QK2 · PDBe 7QK2 · UniProt P10636

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