MolNFT v1 · #185864 · protein
Structure of recombinant human gamma-tubulin ring complex 8-spoked assembly intermediate (spokes 7-14)
7QJ3 · Tubulin gamma-1 chain: “Structure of recombinant human gamma-tubulin ring complex 8-spoked assembly intermediate (spokes 7-14)”. Electron microscopy, 20 pockets (best druggability 0.90). MolNFT v1 #185864 on GenesisL1: 3D structure…
- PDB
- 7QJ3
- Type
- protein
- Length
- 8,521 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin gamma-1 chain; Mitotic-spindle organizing protein 1; Gamma-tubulin complex…
- UniProt
- P23258, Q08AG7, Q96CW5, Q96RT8, Q9BSJ2, Q9UGJ1, Q96RT7
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 11 distinct chains · 61% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2, U, V, W, X, Y, Z | Tubulin gamma-1 chain | protein | 420 | 42% helix, 15% strand | P23258 |
| o, m, b | Mitotic-spindle organizing protein 1 | protein | 65 | 75% helix, 0% strand | Q08AG7 |
| n | Gamma-tubulin complex component 3 | protein | 99 | 60% helix, 0% strand | Q96CW5 |
| l | Gamma-tubulin complex component 5 | protein | 108 | 66% helix, 0% strand | Q96RT8 |
| a | Gamma-tubulin complex component 3 | protein | 116 | 54% helix, 0% strand | Q96CW5 |
| G, M | Gamma-tubulin complex component 2 | protein | 636 | 59% helix, 3% strand | Q9BSJ2 |
| H, N | Gamma-tubulin complex component 3 | protein | 594 | 66% helix, 3% strand | Q96CW5 |
| I | Gamma-tubulin complex component 4 | protein | 521 | 63% helix, 2% strand | Q9UGJ1 |
| J | Gamma-tubulin complex component 5 | protein | 534 | 63% helix, 0% strand | Q96RT8 |
| K | Gamma-tubulin complex component 4 | protein | 562 | 66% helix, 2% strand | Q9UGJ1 |
| L | Gamma-tubulin complex component 6 | protein | 566 | 61% helix, 1% strand | Q96RT7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1036 | 0.90 | 0.91 | 125 | empty |
| 2 | 1171 | 0.88 | 0.89 | 142 | empty |
| 3 | 817 | 0.88 | 0.91 | 133 | empty |
| 4 | 628 | 0.84 | 0.88 | 104 | empty |
| 5 | 400 | 0.84 | 0.91 | 69 | empty |
Interfaces
41 interfaces between chains.
- 2–N · 2795 Ų buried · 30 hydrogen bonds · protein-protein
- 1–M · 2453 Ų buried · 21 hydrogen bonds · protein-protein
- o–n · 2228 Ų buried · 14 hydrogen bonds · protein-protein
- b–a · 2226 Ų buried · 14 hydrogen bonds · protein-protein
- K–L · 2140 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7QJ3 · Structure of recombinant human gamma-Tubulin Ring Complex 8-spoked assembly intermediate… · the same entry in another collection · chain a against a, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23258
- Every structure of UniProt Q08AG7
- Every structure of UniProt Q96CW5
- Every structure of UniProt Q96RT8
- Every structure of UniProt Q9BSJ2
- Every structure of UniProt Q9UGJ1
- Every structure of UniProt Q96RT7
- Elsewhere: RCSB PDB 7QJ3 · PDBe 7QJ3 · UniProt P23258 · UniProt Q08AG7 · UniProt Q96CW5 · UniProt Q96RT8 · UniProt Q9BSJ2 · UniProt Q9UGJ1 · UniProt Q96RT7
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