MolNFT v1 · #185863 · protein
Structure of recombinant human gamma-tubulin ring complex 8-spoked assembly intermediate (spokes 5-12)
7QJ2 · Gamma-tubulin complex component 5: “Structure of recombinant human gamma-tubulin ring complex 8-spoked assembly intermediate (spokes 5-12)”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #185863 on GenesisL1…
- PDB
- 7QJ2
- Type
- protein
- Length
- 8,532 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-tubulin complex component 5; Gamma-tubulin complex component 3; Mitotic-spindle…
- UniProt
- Q96RT8, Q96CW5, Q08AG7, Q9BSJ2, Q9UGJ1, Q96RT7, P23258
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 13 distinct chains · 60% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| l | Gamma-tubulin complex component 5 | protein | 108 | 65% helix, 0% strand | Q96RT8 |
| j | Gamma-tubulin complex component 3 | protein | 99 | 62% helix, 0% strand | Q96CW5 |
| m, k, b | Mitotic-spindle organizing protein 1 | protein | 65 | 71% helix, 0% strand | Q08AG7 |
| E | Gamma-tubulin complex component 2 | protein | 638 | 57% helix, 2% strand | Q9BSJ2 |
| F | Gamma-tubulin complex component 3 | protein | 599 | 60% helix, 1% strand | Q96CW5 |
| G | Gamma-tubulin complex component 2 | protein | 640 | 57% helix, 3% strand | Q9BSJ2 |
| H | Gamma-tubulin complex component 3 | protein | 594 | 68% helix, 3% strand | Q96CW5 |
| I | Gamma-tubulin complex component 4 | protein | 521 | 64% helix, 2% strand | Q9UGJ1 |
| J | Gamma-tubulin complex component 5 | protein | 534 | 65% helix, 1% strand | Q96RT8 |
| K | Gamma-tubulin complex component 4 | protein | 562 | 67% helix, 1% strand | Q9UGJ1 |
| L | Gamma-tubulin complex component 6 | protein | 566 | 60% helix, 1% strand | Q96RT7 |
| a | Gamma-tubulin complex component 3 | protein | 116 | 53% helix, 0% strand | Q96CW5 |
| S, T, U, V, W, X, Y, Z | Tubulin gamma-1 chain | protein | 420 | 42% helix, 16% strand | P23258 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1067 | 0.89 | 0.90 | 138 | empty |
| 2 | 640 | 0.87 | 0.91 | 107 | empty |
| 3 | 1114 | 0.85 | 0.86 | 138 | empty |
| 4 | 375 | 0.85 | 0.93 | 51 | empty |
| 5 | 1086 | 0.85 | 0.85 | 140 | empty |
Interfaces
44 interfaces between chains.
- E–S · 2642 Ų buried · 24 hydrogen bonds · protein-protein
- F–T · 2421 Ų buried · 14 hydrogen bonds · protein-protein
- K–L · 2281 Ų buried · 13 hydrogen bonds · protein-protein
- H–V · 2188 Ų buried · 18 hydrogen bonds · protein-protein
- b–a · 2168 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7QJ2 · Structure of recombinant human gamma-Tubulin Ring Complex 8-spoked assembly intermediate… · the same entry in another collection · chain m against m, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RT8
- Every structure of UniProt Q96CW5
- Every structure of UniProt Q08AG7
- Every structure of UniProt Q9BSJ2
- Every structure of UniProt Q9UGJ1
- Every structure of UniProt Q96RT7
- Every structure of UniProt P23258
- Elsewhere: RCSB PDB 7QJ2 · PDBe 7QJ2 · UniProt Q96RT8 · UniProt Q96CW5 · UniProt Q08AG7 · UniProt Q9BSJ2 · UniProt Q9UGJ1 · UniProt Q96RT7 · UniProt P23258
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