MolNFT v1 · #185830 · protein

Lim domain kinase 2 (LIMK2) in complex with th-470

7QHG: “Lim domain kinase 2 (LIMK2) in complex with th-470”. X-ray diffraction, 1 ligand (T3B). MolNFT v1 #185830 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7QHG
Type: protein
Length: 566 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P53671
Ligands: T3B

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	283	—	P53671
B	—	protein	283	—	P53671

Ligands and binding sites

T3B · 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide · ligand · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7QHG · LIM domain kinase 2 (LIMK2) in complex with TH-470 · the same entry in another collection · chain A against A, TM-score 1.00
P53671 · AlphaFold monomer V2.0 prediction for lim domain kinase 2 (P53671) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53671
Elsewhere: RCSB PDB 7QHG · PDBe 7QHG · UniProt P53671

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