MolNFT v1 · #185613 · protein
Structure of the mouse cplane-RSG1 complex
7Q3E · Wd repeat-containing and planar cell polarity effector…: “Structure of the mouse cplane-RSG1 complex”. Electron microscopy, 1 ligand (GTP), 20 pockets (best druggability 0.80). MolNFT v1 #185613 on GenesisL1: 3D structure, binding…
- PDB
- 7Q3E
- Type
- protein
- Length
- 1,672 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing and planar cell polarity effector protein fritz homolog; Protein…
- UniProt
- Q8C456, Q059U7, E9QL29, A2A825
- Ligands
- GTP
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing and planar cell polarity effector protein fritz homolog | protein | 551 | 26% helix, 35% strand | Q8C456 |
| B | Protein inturned | protein | 503 | 40% helix, 25% strand | Q059U7 |
| C | Protein fuzzy homolog | protein | 392 | 37% helix, 29% strand | E9QL29 |
| D | Ciliogenesis and planar polarity effector 2 | protein | 226 | 35% helix, 23% strand | A2A825 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.80 | 0.85 | 62 | empty |
| 2 | 1086 | 0.78 | 0.80 | 91 | empty |
| 3 | 709 | 0.75 | 0.80 | 87 | GTP |
| 4 | 497 | 0.75 | 0.83 | 37 | empty |
| 5 | 1001 | 0.71 | 0.75 | 51 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2886 Ų buried · 36 hydrogen bonds · protein-protein
- B–C · 2292 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 1407 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 423 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7Q3E · Structure of the mouse CPLANE-RSG1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8C456 · AlphaFold monomer V2.0 prediction for wd repeat-containing and planar cell polarity… · a predicted model of the same protein · chain A against A, TM-score 0.97
- A2A825 · AlphaFold monomer V2.0 prediction for ciliogenesis and planar polarity effector 2 (A2A825) · a predicted model of the same protein · chain D against A, TM-score 0.97
- Q059U7 · AlphaFold monomer V2.0 prediction for protein inturned (Q059U7) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8C456
- Every structure of UniProt Q059U7
- Every structure of UniProt E9QL29
- Every structure of UniProt A2A825
- Elsewhere: RCSB PDB 7Q3E · PDBe 7Q3E · UniProt Q8C456 · UniProt Q059U7 · UniProt E9QL29 · UniProt A2A825
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.