MolNFT v1 · #185542 · protein
Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus in the open state with NADP and tartrate
7Q07: “Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus in the open state with NADP and…”. X-ray diffraction, 2 ligands (NAP, CL), 4 pockets (best druggability 0.55). MolNFT v1 #185542 on GenesisL1: 3D structure…
- PDB
- 7Q07
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus
- EC
- 1.1.1.86
- Ligands
- NAP, CL
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus (EC 1.1.1.86) | protein | 327 | 60% helix, 13% strand | — |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- CL · Chloride ion · ion · 3 copies · chains A
- TLA · L(+)-tartaric acid · additive · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 357 | 0.55 | 0.73 | 35 | empty |
| 2 | 199 | 0.47 | 0.75 | 33 | TLA |
| 3 | 78 | 0.36 | 0.76 | 18 | NAP |
| 4 | 50 | 0.32 | 0.78 | 14 | empty |
Compared structures
- 7Q07 · Ketol-acid reductoisomerase from Methanothermococcus thermolithotrophicus in the open… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7Q07 · PDBe 7Q07
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.