MolNFT v1 · #185392 · protein

Crystal structure of the spd-2 domain of human CEP192

7PTB · Centrosomal protein of 192 kda: “Crystal structure of the spd-2 domain of human CEP192”. X-ray diffraction, 1 ligand (NO3), 3 pockets (best druggability 0.44). MolNFT v1 #185392 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7PTB
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centrosomal protein of 192 kda
UniProt: Q8TEP8
Ligands: NO3
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centrosomal protein of 192 kda	protein	317	13% helix, 45% strand	Q8TEP8

Ligands and binding sites

NO3 · Nitrate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.44	0.79	21	empty
2	97	0.39	0.76	18	empty
3	86	0.33	0.74	18	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

7PTB · Crystal structure of the SPD-2 domain of human CEP192 · the same entry in another collection · chain A against A, TM-score 1.00
Q8TEP8 · AlphaFold monomer V2.0 prediction for centrosomal protein of 192 kda (Q8TEP8) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEP8
Elsewhere: RCSB PDB 7PTB · PDBe 7PTB · UniProt Q8TEP8

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