MolNFT v1 · #185313 · protein

HUMAN SLFN5

7PPJ · Schlafen family member 5: “HUMAN SLFN5”. Electron microscopy, 1 ligand (ZN), 8 pockets (best druggability 0.63). MolNFT v1 #185313 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7PPJ
Type: protein
Length: 643 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Schlafen family member 5
UniProt: Q08AF3
Ligands: ZN
Pockets: 8 · best druggability 0.63

Structure

electron microscopy · 1 distinct chain · 32% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Schlafen family member 5	protein	643	32% helix, 21% strand	Q08AF3

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.63	0.79	37	empty
2	268	0.61	0.80	30	empty
3	207	0.47	0.74	31	empty
4	209	0.46	0.74	25	empty
5	64	0.35	0.77	17	empty

Compared structures

7PPJ · human SLFN5 · the same entry in another collection · chain A against A, TM-score 1.00
Q08AF3 · AlphaFold monomer V2.0 prediction for schlafen family member 5 (Q08AF3) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08AF3
Elsewhere: RCSB PDB 7PPJ · PDBe 7PPJ · UniProt Q08AF3

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