MolNFT v1 · #185276 · protein

C terminal domain of nipah virus phosphoprotein fused to the ntail alpha more of the nucleoprotein.

7PNO: “C terminal domain of nipah virus phosphoprotein fused to the ntail alpha more of the nucleoprotein.”. X-ray diffraction, 8 pockets (best druggability 0.54). MolNFT v1 #185276 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7PNO
Type: protein
Length: 486 residues
Chains: 14
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoprotein; Alpha more of nipah virus nucleoprotein tail
UniProt: Q9IK91
Pockets: 8 · best druggability 0.54

Structure

x-ray diffraction · 8 distinct chains · 87% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, I, K, M	Phosphoprotein	protein	49	82% helix, 0% strand	Q9IK91
B	Alpha more of nipah virus nucleoprotein tail	protein	23	87% helix, 0% strand	—
D	Alpha more of nipah virus nucleoprotein tail	protein	24	88% helix, 0% strand	—
F	Alpha more of nipah virus nucleoprotein tail	protein	23	91% helix, 0% strand	—
H	Alpha more of nipah virus nucleoprotein tail	protein	21	90% helix, 0% strand	—
J	Alpha more of nipah virus nucleoprotein tail	protein	14	86% helix, 0% strand	—
L	Alpha more of nipah virus nucleoprotein tail	protein	18	89% helix, 0% strand	—
N	Alpha more of nipah virus nucleoprotein tail	protein	20	90% helix, 0% strand	—

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.54	0.78	39	empty
2	155	0.47	0.77	26	empty
3	156	0.46	0.76	28	empty
4	172	0.45	0.76	26	empty
5	90	0.43	0.79	20	empty

Interfaces

23 interfaces between chains.

A–B · 514 Å² buried · 6 hydrogen bonds · protein-protein
M–N · 514 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 512 Å² buried · 9 hydrogen bonds · protein-protein
G–H · 509 Å² buried · 5 hydrogen bonds · protein-protein
A–I · 487 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7PNO · C terminal domain of Nipah Virus Phosphoprotein fused to the Ntail alpha more of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9IK91
Elsewhere: RCSB PDB 7PNO · PDBe 7PNO · UniProt Q9IK91

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