MolNFT v1 · #184893 · protein
Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament
7P6C · Microtubule-associated protein tau: “Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament”. Electron microscopy, 9 pockets (best druggability 0.70). MolNFT v1 #184893 on GenesisL1: 3D structure, binding sites…
- PDB
- 7P6C
- Type
- protein
- Length
- 1,080 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 9 · best druggability 0.70
Structure
electron microscopy · 1 distinct chain · 0% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Microtubule-associated protein tau | protein | 108 | 0% helix, 62% strand | P10636 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 817 | 0.70 | 0.76 | 69 | empty |
| 2 | 835 | 0.70 | 0.76 | 62 | empty |
| 3 | 68 | 0.61 | 0.90 | 29 | empty |
| 4 | 55 | 0.56 | 0.90 | 30 | empty |
| 5 | 95 | 0.35 | 0.74 | 23 | empty |
Interfaces
33 interfaces between chains.
- A–D · 4504 Ų buried · 153 hydrogen bonds · protein-protein
- D–E · 4503 Ų buried · 149 hydrogen bonds · protein-protein
- A–B · 4502 Ų buried · 149 hydrogen bonds · protein-protein
- F–I · 4497 Ų buried · 152 hydrogen bonds · protein-protein
- B–C · 4497 Ų buried · 152 hydrogen bonds · protein-protein
Compared structures
- 7P6C · Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7P6C · PDBe 7P6C · UniProt P10636
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