MolNFT v1 · #184892 · protein

Limbic-predominant neuronal inclusion body 4R tauopathy type 1B tau filament

7P6B · Microtubule-associated protein tau: “Limbic-predominant neuronal inclusion body 4R tauopathy type 1B tau filament”. Electron microscopy, 4 pockets (best druggability 0.74). MolNFT v1 #184892 on GenesisL1: 3D structure, binding sites…

PDB: 7P6B
Type: protein
Length: 540 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 4 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 0% helix, 65% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Microtubule-associated protein tau	protein	108	0% helix, 65% strand	P10636

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1000	0.74	0.77	69	empty
2	89	0.33	0.73	21	empty
3	61	0.29	0.74	17	empty
4	70	0.28	0.72	16	empty

Interfaces

7 interfaces between chains.

B–C · 4624 Å² buried · 159 hydrogen bonds · protein-protein
A–D · 4622 Å² buried · 159 hydrogen bonds · protein-protein
A–B · 4621 Å² buried · 158 hydrogen bonds · protein-protein
D–E · 4618 Å² buried · 158 hydrogen bonds · protein-protein
A–C · 150 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7P6B · Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 7P6B · PDBe 7P6B · UniProt P10636

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