MolNFT v1 · #184737 · protein + RNA
Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snrna stem-loop 4
7P0V · Isoform 2 of splicing factor 3A subunit 1: “Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snrna stem-loop 4”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.54). MolNFT v1 #184737 on…
- PDB
- 7P0V
- Type
- protein + RNA
- Length
- 114 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of splicing factor 3A subunit 1; RNA (5'…
- UniProt
- Q15459
- Ligands
- NA
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of splicing factor 3A subunit 1 | protein | 90 | 20% helix, 34% strand | Q15459 |
| B | RNA (5'- R(P*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP *CP*C)-3') | rna | 24 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.54 | 0.78 | 27 | empty |
| 2 | 63 | 0.51 | 0.87 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 631 Ų buried · 16 hydrogen bonds · protein-nucleic
Compared structures
- 7P0V · Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snRNA stem-loop… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15459 · AlphaFold monomer V2.0 prediction for splicing factor 3A subunit 1 (Q15459) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15459
- Elsewhere: RCSB PDB 7P0V · PDBe 7P0V · UniProt Q15459
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