MolNFT v1 · #184734 · protein
Orf virus encoded BCL-2 homolog ORFV125 in complex with puma BH3 peptide
7P0S · Apoptosis inhibitor: “Orf virus encoded BCL-2 homolog ORFV125 in complex with puma BH3 peptide”. X-ray diffraction, 2 pockets (best druggability 0.78). MolNFT v1 #184734 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7P0S
- Type
- protein
- Length
- 316 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis inhibitor; BCL-2-binding component 3, isoforms 1/2
- UniProt
- A0A0R8HV90, Q9BXH1
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis inhibitor | protein | 137 | 80% helix, 0% strand | A0A0R8HV90 |
| U | BCL-2-binding component 3, isoforms 1/2 | protein | 24 | 75% helix, 0% strand | Q9BXH1 |
| B | Apoptosis inhibitor | protein | 132 | 77% helix, 0% strand | A0A0R8HV90 |
| C | BCL-2-binding component 3, isoforms 1/2 | protein | 23 | 87% helix, 0% strand | Q9BXH1 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.78 | 0.91 | 34 | empty |
| 2 | 143 | 0.54 | 0.80 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2842 Ų buried · 33 hydrogen bonds · protein-protein
- A–U · 918 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 914 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7P0S · ORF virus encoded Bcl-2 homolog ORFV125 in complex with Puma BH3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BXH1 · AlphaFold monomer V2.0 prediction for BCL-2-binding component 3, isoforms 1/2 (Q9BXH1) · a predicted model of the same protein · chain C against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0R8HV90
- Every structure of UniProt Q9BXH1
- Elsewhere: RCSB PDB 7P0S · PDBe 7P0S · UniProt A0A0R8HV90 · UniProt Q9BXH1
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