MolNFT v1 · #18470 · protein

Crystal structure of BCL-XL/BIM

1PQ1 · Apoptosis regulator BCL-X: “Crystal structure of BCL-XL/BIM”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #18470 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PQ1
Type: protein
Length: 180 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis regulator BCL-X; BCL2-like protein 11
UniProt: Q64373, O54918
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apoptosis regulator BCL-X	protein	147	72% helix, 0% strand	Q64373
B	BCL2-like protein 11	protein	33	82% helix, 0% strand	O54918

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.47	0.84	15	empty

Interfaces

1 interface between chains.

A–B · 1119 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1PQ1 · Crystal structure of Bcl-xl/Bim · the same entry in another collection · chain B against B, TM-score 1.00
Q64373 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q64373) · a predicted model of the same protein · chain A against A, TM-score 0.95
O54918 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O54918) · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64373
Every structure of UniProt O54918
Elsewhere: RCSB PDB 1PQ1 · PDBe 1PQ1 · UniProt Q64373 · UniProt O54918

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