MolNFT v1 · #184691 · protein

Pmca-amplified alpha-synuclein fibril polymorph, PARKINSON'S disease patient-derived seeds

7OZG: “Pmca-amplified alpha-synuclein fibril polymorph, PARKINSON'S disease patient-derived seeds”. Electron microscopy, 3 pockets (best druggability 0.48). MolNFT v1 #184691 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7OZG
Type: protein
Length: 730 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-synuclein
UniProt: P37840
Pockets: 3 · best druggability 0.48

Structure

electron microscopy · 1 distinct chain · 0% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Alpha-synuclein	protein	73	0% helix, 38% strand	P37840

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.48	0.79	27	empty
2	136	0.46	0.77	25	empty
3	94	0.31	0.72	22	empty

Interfaces

27 interfaces between chains.

E–G · 2828 Å² buried · 90 hydrogen bonds · protein-protein
A–C · 2826 Å² buried · 90 hydrogen bonds · protein-protein
C–E · 2826 Å² buried · 90 hydrogen bonds · protein-protein
G–I · 2825 Å² buried · 90 hydrogen bonds · protein-protein
B–D · 2820 Å² buried · 90 hydrogen bonds · protein-protein

Compared structures

7OZG · PMCA-amplified alpha-synuclein fibril polymorph, Parkinson's Disease patient-derived seeds · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37840
Elsewhere: RCSB PDB 7OZG · PDBe 7OZG · UniProt P37840

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.