MolNFT v1 · #184640 · protein
Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6.
7OXB: “Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6.”. X-ray diffraction, 1 ligand (35Z). MolNFT v1 #184640 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OXB
- Type
- protein
- Length
- 305 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00533
- Ligands
- 35Z
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 305 | — | P00533 |
Ligands and binding sites
- 35Z · 2-[2-(3-methoxyphenyl)pyrimidin-4-yl]-1'-prop-2-enoyl-spiro[5,6-dihydro-1~{H}-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OXB · Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6. · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 7OXB · PDBe 7OXB · UniProt P00533
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