MolNFT v1 · #184628 · protein

Structure of cyld cap-GLY3 (467-552) bound to ub; tetragonal space group

7OWD · Ubiquitin carboxyl-terminal hydrolase cyld: “Structure of cyld cap-GLY3 (467-552) bound to ub; tetragonal space group”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #184628 on GenesisL1: 3D structure, binding…

PDB: 7OWD
Type: protein
Length: 160 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase cyld; Ubiquitin
EC: 3.4.19.12
UniProt: Q9NQC7, P0CG48
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Ubiquitin carboxyl-terminal hydrolase cyld (EC 3.4.19.12)	protein	84	4% helix, 38% strand	Q9NQC7
A	Ubiquitin	protein	76	24% helix, 34% strand	P0CG48

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.38	0.79	20	empty

Interfaces

1 interface between chains.

B–A · 628 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7OWD · Structure of CYLD CAP-Gly3 (467-552) bound to Ub; tetragonal space group · the same entry in another collection · chain B against B, TM-score 1.00
Q9NQC7 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase cyld (Q9NQC7) · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NQC7
Every structure of UniProt P0CG48
Elsewhere: RCSB PDB 7OWD · PDBe 7OWD · UniProt Q9NQC7 · UniProt P0CG48

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