Heterodimeric murine tRNA-guanine transglycosylase in complex with queuine

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).

Ligands and binding sites

• QEI · 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one · ligand · chains C
• ZN · Zinc ion · metal · 2 copies · chains A, C
• SO4 · Sulfate ion · ion · 7 copies · chains A, C
• DMS · Dimethyl sulfoxide · additive · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–C · 1544 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 7OVO · Heterodimeric murine tRNA-guanine transglycosylase in complex with queuine · the same entry in another collection · chain A against A, TM-score 1.00
• B8ZXI1 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase accessory subunit 2… · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9JMA2 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase catalytic subunit 1… · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt B8ZXI1
• Every structure of UniProt Q9JMA2
• Elsewhere: RCSB PDB 7OVO · PDBe 7OVO · UniProt B8ZXI1 · UniProt Q9JMA2