MolNFT v1 · #184404 · protein
Cryo-EM structure of P5B-ATPase E2PISPM
7OP3 · Cation-transporting ATPase: “Cryo-EM structure of P5B-ATPase E2PISPM”. Electron microscopy, 1 ligand (SPM), 20 pockets (best druggability 0.75). MolNFT v1 #184404 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OP3
- Type
- protein
- Length
- 1,100 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation-transporting ATPase
- EC
- 7.2.2.-
- UniProt
- G0S7G9
- Ligands
- SPM
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cation-transporting ATPase (EC 7.2.2.-) | protein | 1100 | 39% helix, 14% strand | G0S7G9 |
Ligands and binding sites
- SPM · Spermine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.75 | 0.78 | 79 | empty |
| 2 | 478 | 0.71 | 0.81 | 56 | empty |
| 3 | 621 | 0.67 | 0.77 | 63 | empty |
| 4 | 307 | 0.63 | 0.79 | 32 | empty |
| 5 | 157 | 0.61 | 0.84 | 29 | SPM |
Compared structures
- 7OP3 · Cryo-EM structure of P5B-ATPase E2PiSPM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S7G9
- Elsewhere: RCSB PDB 7OP3 · PDBe 7OP3 · UniProt G0S7G9
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