MolNFT v1 · #184402 · protein

Cryo-EM structure of P5B-ATPase E2PIALF/SPM

7OP1 · Cation-transporting ATPase: “Cryo-EM structure of P5B-ATPase E2PIALF/SPM”. Electron microscopy, 3 ligands (ALF, SPM, MG), 15 pockets (best druggability 0.80). MolNFT v1 #184402 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7OP1
Type: protein
Length: 1,098 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cation-transporting ATPase
EC: 7.2.2.-
UniProt: G0S7G9
Ligands: ALF, SPM, MG
Pockets: 15 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cation-transporting ATPase (EC 7.2.2.-)	protein	1098	42% helix, 16% strand	G0S7G9

Ligands and binding sites

ALF · Tetrafluoroaluminate ion · ligand · chains A
SPM · Spermine · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	874	0.80	0.82	86	empty
2	773	0.73	0.78	80	empty
3	192	0.68	0.86	26	SPM
4	359	0.64	0.79	30	empty
5	110	0.57	0.85	24	empty

Compared structures

7OP1 · Cryo-EM structure of P5B-ATPase E2PiAlF/SPM · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S7G9
Elsewhere: RCSB PDB 7OP1 · PDBe 7OP1 · UniProt G0S7G9

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