MolNFT v1 · #184181 · protein
A cooperative pnpase-hfq-RNA carrier complex facilitates bacterial riboregulation. apo-pnpase
7OGL · Polyribonucleotide nucleotidyltransferase: “A cooperative pnpase-hfq-RNA carrier complex facilitates bacterial riboregulation. apo-pnpase”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #184181 on GenesisL1: 3D…
- PDB
- 7OGL
- Type
- protein
- Length
- 2,079 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyribonucleotide nucleotidyltransferase
- EC
- 2.7.7.8
- UniProt
- P05055
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) | protein | 689 | 34% helix, 27% strand | P05055 |
| B, C | Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) | protein | 695 | 32% helix, 28% strand | P05055 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1198 | 0.86 | 0.88 | 163 | empty |
| 2 | 887 | 0.84 | 0.86 | 95 | empty |
| 3 | 297 | 0.64 | 0.81 | 41 | empty |
| 4 | 407 | 0.61 | 0.77 | 39 | empty |
| 5 | 324 | 0.59 | 0.78 | 42 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1710 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1696 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1651 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7OGL · A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation.… · the same entry in another collection · chain A against A, TM-score 1.00
- P05055 · AlphaFold monomer V2.0 prediction for polyribonucleotide nucleotidyltransferase (P05055) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05055
- Elsewhere: RCSB PDB 7OGL · PDBe 7OGL · UniProt P05055
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